Lowes.syf.com/activate is the official website for activating new credit cards from Lowe's so you can start using your card's benefits and rewards. Activate your Lowe's credit card to enjoy seamless shopping experiences online, in-store, or through the Lowe's mobile app. Lowes.syf.com/activate is the official website for activating new credit cards from Lowe's so you can start using your card's benefits and rewards. Once activation is complete, you can immediately start enjoying special financing options, Lowe's cardholder discounts, and rewards on Lowe's purchases.